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  <title>Pediatric Dosing</title>
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    <div id="xsTitle" class="tableTitle visible-xs"  style="visibility:hidden">Pediatric Dosing</div>
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 <div class="dataTable">
   <div class="fixedHeaders">
        <table class="mainTableHeaders">
          <thead>
            <tr class="tableHeader">
              <td class="colHeader ped-col-1"> <br/>Drug </td>
              <td class="colHeader ped-col-2"> Dose<br/>(Age >28 Days)</td>
              <td class="colHeader ped-col-3"> <br/>Max/Day</td>
            </tr>
          </thead>
        </table>
      </div>
   <div class="dataRows">
     <table class="mainTable" id="mainTable">
    
      
       <tr class="drugFamily">
         <td colspan="3"><b> Antibacterials </b></td>
       </tr>
    
      
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/aminoglycosides-overview">Aminoglycosides</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/amikacin"> Amikacin </a></td>
      
         <td class="ped-col-2">15-20 mg/kg q24h; 5-7.5 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/gentamicin"> Gentamicin </a></td>
      
         <td class="ped-col-2">5-7 mg/kg q24h; 2.5 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/tobramycin"> Tobramycin </a></td>
      
         <td class="ped-col-2">5-7 mg/kg q24h; 2.5 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/comparisons-1/adverse-effects/penicillin-beta-lactam-allergy">Beta-Lactams</a></td>
       </tr>

      
       <tr class="drugSubClass">
         <td colspan="3"> Carbapenems </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/carbapenems/ertapenem"> Ertapenem </a></td>
      
         <td class="ped-col-2">30 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/carbapenems/imipenem-cilastatin"> Imipenem </a></td>
      
         <td class="ped-col-2">60-100 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">2-4 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/carbapenems/meropenem"> Meropenem </a></td>
      
         <td class="ped-col-2">60 mg/kg/day (divided q8h)
Meningitis: 120 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugSubClass">
         <td colspan="3"> Cephalosporins (po) </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/cefaclor"> Cefaclor </a></td>
      
         <td class="ped-col-2">20-40 mg/kg/day (divided q8-12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/1st-generation/cefadroxil"> Cefadroxil </a></td>
      
         <td class="ped-col-2">30 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/cefdinir"> Cefdinir </a></td>
      
         <td class="ped-col-2">14 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/cefixime"> Cefixime </a></td>
      
         <td class="ped-col-2">8 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/cefpodoxime-proxetil"> Cefpodoxime </a></td>
      
         <td class="ped-col-2">10 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">400 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/cefprozil"> Cefprozil </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (divided q12h) -- use 30 for AOM </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/ceftibuten"> Ceftibuten </a></td>
      
         <td class="ped-col-2">9 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/cefuroxime-axetil"> Cefuroxime axetil </a></td>
      
         <td class="ped-col-2">20-30 mg/kg/day (divided q12h) -- use 30 for AOM </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/1st-generation/cephalexin"> Cephalexin </a></td>
      
         <td class="ped-col-2">25-100 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">4 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/loracarbef"> Loracarbef </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">800 mg  </td>
       </tr>
       <tr class="drugSubClass">
         <td colspan="3"> Cephalosporins (IV) </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/1st-generation/cefazolin"> Cefazolin </a></td>
      
         <td class="ped-col-2">50-150 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/cefepime"> Cefepime (non-Pseudomonal) </a></td>
      
         <td class="ped-col-2">100 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/cefepime"> Cefepime (Pseudomonal) </a></td>
      
         <td class="ped-col-2">150 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/cefotaxime"> Cefotaxime </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6-8h)
Meningitis: 300 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/2nd-generation/cefotetan"> Cefotetan </a></td>
      
         <td class="ped-col-2">60-100 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/2nd-generation/cefoxitin"> Cefoxitin </a></td>
      
         <td class="ped-col-2">80-160 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftaroline"> Ceftaroline </a></td>
      
         <td class="ped-col-2">2 mon to &lt;2 yrs: 8 mg/kg q8h
≥2 yrs to &lt;18 yrs, ≤33 kg: 12 mg/kg q8h
≥2 yrs to &lt;18 yrs, &gt;33 kg: 400 mg q8h or 600 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftazidime-avibactam"> Ceftazidime </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q8h)
CF: 300 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftizoxime"> Ceftizoxime </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftriaxone"> Ceftriaxone </a></td>
      
         <td class="ped-col-2">50-100 mg/kg q24h
Meningitis: 50 mg/kg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/2nd-generation/cefuroxime"> Cefuroxime </a></td>
      
         <td class="ped-col-2">150 mg/kg/day (divided q8h)
Meningitis: 80 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugSubClass">
         <td colspan="3"> Penicillins </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin"> Amoxicillin </a></td>
      
         <td class="ped-col-2">25-50 mg/kg/day (divided q8h)  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin"> Amoxicillin (AOM, pneumonia) </a></td>
      
         <td class="ped-col-2">80-100 mg/kg/day (divided q8-12h; q12h for AOM) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin-clavulanate"> Amoxicillin-clavulanate 7:1 formulation </a></td>
      
         <td class="ped-col-2">45 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin-clavulanate"> Amoxicillin-clavulanate 14:1  (AOM) </a></td>
      
         <td class="ped-col-2">90 mg/kg/day (divided q12h) for wt &lt;40 kg </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/ampicillin"> Ampicillin (IV) </a></td>
      
         <td class="ped-col-2">200 mg/kg/day (divided q6h)
Meningitis: 300-400 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/ampicillin-sulbactam"> Ampicillin-sulbactam </a></td>
      
         <td class="ped-col-2">100-300 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/cloxacillin"> Cloxacillin (PO) </a></td>
      
         <td class="ped-col-2">If &lt;20 kg: 25-50 mg/kg/day (divided q6h)
Otherwise dose as adult </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/dicloxacin"> Dicloxacillin (mild - moderate) </a></td>
      
         <td class="ped-col-2">12.5-25 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/dicloxacin"> Dicloxacillin (osteo articular infection) </a></td>
      
         <td class="ped-col-2">100 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/flucloxacin"> Flucloxacillin </a></td>
      
         <td class="ped-col-2">Age &lt;2: 25% of adult dose
Age 2-10: 50% of adult dose </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/nafcillin"> Nafcillin </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/oxacillin"> Oxacillin </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/penicillin-g"> Penicillin G </a></td>
      
         <td class="ped-col-2">150,000-300,000 units/kg/day (divided q4-6h) </td>
         <td class="ped-col-3">12-20 million units  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/penicillin-v"> Penicillin VK </a></td>
      
         <td class="ped-col-2">25-75 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/anti-pseudomonal-penicillins/piperacillin-tazobactam"> Piperacillin-tazobactam </a></td>
      
         <td class="ped-col-2">300 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/temocillin"> Temocillin </a></td>
      
         <td class="ped-col-2">25 mg/kg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/fluoroquinolones-overview">Fluoroquinolones</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/ciprofloxacin"> Ciprofloxacin (PO) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Approved only for CF, anthrax, and complicated UTI" data-header="Ciprofloxacin (PO)">20-40 mg/kg/day (divided q12h) <span class="supascript">*</span></a></td>
         <td class="ped-col-3">1.5 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/ciprofloxacin"> Ciprofloxacin (IV) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Approved only for CF, anthrax, and complicated UTI" data-header="Ciprofloxacin (IV)">20-30 mg/kg/day (divided q12h) <span class="supascript">*</span></a></td>
         <td class="ped-col-3">1.2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/levofloxacin"> Levofloxacin (IV/PO) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Approved only for CF, anthrax, and complicated UTI" data-header="Levofloxacin (IV/PO)">16-20 mg/kg/day (divided q12h) <span class="supascript">*</span></a></td>
         <td class="ped-col-3">750 mg  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Lincosamides</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/clindamycin-1/clindamycin"> Clindamycin (PO) </a></td>
      
         <td class="ped-col-2">30-40 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/clindamycin-1/clindamycin"> Clindamycin (IV) </a></td>
      
         <td class="ped-col-2">20-40 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/clindamycin-1/lincomycin"> Lincomycin </a></td>
      
         <td class="ped-col-2">10-20 mg/kg/day (divided q8-12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Lipopeptides</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/glyco-lipoglyco-peptides/daptomycin"> Daptomycin </a></td>
      
         <td class="ped-col-2">6-10 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/macrolides-overview">Macrolides</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/azithromycin"> Azithromycin (po) </a></td>
      
         <td class="ped-col-2">5-12 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/azithromycin"> Azithromycin (IV) </a></td>
      
         <td class="ped-col-2">10 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/clarithromycin"> Clarithromycin </a></td>
      
         <td class="ped-col-2">15 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/erythromycin-base-esters"> Erythromycin (po, IV) </a></td>
      
         <td class="ped-col-2">40-50 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Monobactams</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/monobactam/aztreonam"> Aztreonam </a></td>
      
         <td class="ped-col-2">90-120 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">8 gm  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/tetracycline">Tetracyclines</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/doxycycline"> Doxycycline (po/IV, age &gt;8 yrs) </a></td>
      
         <td class="ped-col-2">2-4 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">200 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/minocycline"> Minocycline (PO, age &gt;8) </a></td>
      
         <td class="ped-col-2">4 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/tetracycline"> Tetracycline </a></td>
      
         <td class="ped-col-2">Age &gt;8: 25-50 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Other</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/chloramphenicol"> Chloramphenicol (IV) </a></td>
      
         <td class="ped-col-2">50-100 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">2-4 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/polymyxins/polymyxin-e-colistin"> Colistin </a></td>
      
         <td class="ped-col-2">2.5-5 mg/kg/day (divided q6-12h)
CF: 3-8 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/fosfomycin"> Fosfomycin (PO) </a></td>
      
         <td class="ped-col-2">2 gm once </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fusidanes/fusidic-acid"> Fusidic acid (PO) </a></td>
      
         <td class="ped-col-2">Age 1-5: 250 mg q8h
Age 6-12: 250-500 mg q8h  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/oxazolidinones/linezolid-zyvox"> Linezolid (up to age 12 yrs) </a></td>
      
         <td class="ped-col-2">30 mg/kg/day IV/po (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/methenamine-hippurate"> Methenamine hippurate (age 6-12) </a></td>
      
         <td class="ped-col-2">500-1000 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/methenamine-hippurate"> Methenamine mandelate </a></td>
      
         <td class="ped-col-2">Age &gt;2 to 6: 50-75 mg/kg/day (divided q6-8h)
Age 6-12: 500 mg q6h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/nitroimidazoles/metronidazole"> Metronidazole (PO) </a></td>
      
         <td class="ped-col-2">30-40 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/nitroimidazoles/metronidazole"> Metronidazole (IV) </a></td>
      
         <td class="ped-col-2">22.5-40 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/nitrofurantoin"> Nitrofurantoin (PO Cystitis) </a></td>
      
         <td class="ped-col-2">5-7 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/nitrofurantoin"> Nitrofurantoin (PO UTI prophylaxis) </a></td>
      
         <td class="ped-col-2">1-2 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/polymyxins/polymixin-b"> Polymyxin B (age 2 and older) </a></td>
      
         <td class="ped-col-2">2.5 mg/kg (load), then 1.5 mg/kg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifampin"> Rifampin (meningococcal prophylaxis) </a></td>
      
         <td class="ped-col-2">10 mg/kg q12h x2 days </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/nitroimidazoles/tinidazole"> Tinidazole (age &gt;3 for Giardia, amebiasis) </a></td>
      
         <td class="ped-col-2">50 mg/kg q24h x1-5 days </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiparasitic-agents/sulfadiazine"> Sulfadiazine </a></td>
      
         <td class="ped-col-2">120-150 mg/kg/day (divided q4-6h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/trimethoprim-sulfonamides/trimethoprim-sulfamethoxazole"> TMP-SMX (UTI and other)  </a></td>
      
         <td class="ped-col-2"> 8-12 mg TMP/kg/day (divided q12h)  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/trimethoprim-sulfonamides/trimethoprim-sulfamethoxazole"> TMP-SMX (PCP) </a></td>
      
         <td class="ped-col-2">15-20 mg TMP/kg/day (divided q12h)  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/trimethoprim-sulfonamides/trimethoprim"> Trimethoprim </a></td>
      
         <td class="ped-col-2">4 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/glyco-lipoglyco-peptides/vancomycin"> Vancomycin (IV) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Use serum concentration to target trough 10-15 mcg/mL; 60 mg/kg/day most likely to achieve target" data-header="Vancomycin (IV)">40-60 mg/kg/day (divided q6-8h)<span class="supascript">*</span></a></td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/glyco-lipoglyco-peptides/vancomycin"> Vancomycin (PO for C. difficile) </a></td>
      
         <td class="ped-col-2">40 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antimycobacterials </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/capreomycin-sulfate"> Capreomycin </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/cycloserine"> Cycloserine </a></td>
      
         <td class="ped-col-2">10-15 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/ethambutol"> Ethambutol </a></td>
      
         <td class="ped-col-2">15-25 mg/kg/day (once daily) </td>
         <td class="ped-col-3">2.5 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/ethionamide"> Ethionamide </a></td>
      
         <td class="ped-col-2">15-20 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/isoniazid"> Isoniazid (daily dosing) </a></td>
      
         <td class="ped-col-2">10-15 mg/kg/day (once daily) </td>
         <td class="ped-col-3">300 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/isoniazid"> Isoniazid (2 x/week) </a></td>
      
         <td class="ped-col-2">20-30 mg/kg twice weekly </td>
         <td class="ped-col-3">900 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/kanamycin"> Kanamycin </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (once daily) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/para-aminosalicylic-acid"> Para-aminosalicylic acid </a></td>
      
         <td class="ped-col-2">200-300 mg/kg/day (divided q6-12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/pyrazinamide"> Pyrazinamide (daily) </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (once daily) </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/pyrazinamide"> Pyrazinamide (2 x/week) </a></td>
      
         <td class="ped-col-2">50 mg/kg twice weekly </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifabutin"> Rifabutin (MAC prophylaxis) </a></td>
      
         <td class="ped-col-2">5 mg/kg/day (once daily) </td>
         <td class="ped-col-3">300 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifabutin"> Rifabutin (active TB) </a></td>
      
         <td class="ped-col-2">10-20 mg/kg/day (once daily) </td>
         <td class="ped-col-3">300 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifampin"> Rifampin </a></td>
      
         <td class="ped-col-2">10-20 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">600 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/streptomycin"> Streptomycin (age 2 and older) </a></td>
      
         <td class="ped-col-2">20-40 mg/kg/day (once daily) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antifungals </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/amphotericin-b"> Amphotericin B deoxycholate </a></td>
      
         <td class="ped-col-2">0.5-1 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/amphotericin-b"> Amphotericin B lipid complex </a></td>
      
         <td class="ped-col-2">5 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/anidulafungin"> Anidulafungin </a></td>
      
         <td class="ped-col-2">1.5-3 mg/kg load, then 0.75-1.5 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/caspofungin"> Caspofungin </a></td>
      
         <td class="ped-col-2">70 mg/m2 load, then 50 mg/m2 (once daily) </td>
         <td class="ped-col-3">70 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/fluconazole"> Fluconazole </a></td>
      
         <td class="ped-col-2">Oral/esophageal Candida: 6 mg/kg/day
Invasive disease: 12 mg/kg/day </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Griseofulvin </td>
      
         <td class="ped-col-2">Tinea capitis: micro susp 20-25 mg/kg/day, ultra tab 10-15 mg/kg/day
(duration ≥6 weeks, continue until clinically clear)
Tinea corporis: micro susp 10-20 mg/kg/day x2-4 weeks
Tinea pedis: micro susp 10-20 mg/kg/day x4-8 weeks </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/isavuconazole"> Isavuconazole </a></td>
      
         <td class="ped-col-2">Not established </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/itraconazole"> Itraconazole </a></td>
      
         <td class="ped-col-2">5-10 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">600 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/ketoconazole"> Ketoconazole </a></td>
      
         <td class="ped-col-2">3.3-6.6 mg/kg/day (once daily) </td>
         <td class="ped-col-3">400 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/micafungin"> Micafungin </a></td>
      
         <td class="ped-col-2">Candidiasis, age &gt;4 mon: 2 mg/kg q24h (max 100 mg)
EC, &lt;30 kg: 3 mg/kg q24h
EC, &gt;30 kg: 2.5 mg/kg q24h (max 150 mg)  </td>
         <td class="ped-col-3">See dose  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/posaconazole"> Posaconazole </a></td>
      
         <td class="ped-col-2">Age 13-17: Oral susp/tabs, use adult dose
Safety/efficacy of injection not established </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/terbinafine"> Terbinafine </a></td>
      
         <td class="ped-col-2">Tinea capitis: 4-6 mg/kg/day (tabs)
Wt 10-20 kg: 62.5 mg q24h
Wt 20-40 kg: 125 mg q24h
Wt &gt;40 kg: 250 mg q24h
Duration: 2 wks for T. tonsurans, 4 wks for M. canis
 </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/voriconazole"> Voriconazole </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Variable bioavailabilty and metabolism. Adjust to trough level 1-6 mcg/mL                                        " data-header="Voriconazole">12-20 mg/kg/day (divided q12h)<span class="supascript">*</span></a></td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antiretrovirals </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/abacavir"> Abacavir (ABC) </a></td>
      
         <td class="ped-col-2">Oral soln, age ≥3 mon:
8 mg/kg q12h or 16 mg/kg q24h (start soln q12h)
Tabs, wt-based:
14 to &lt;20 kg: 150 mg q12h
≥20 to &lt;25 kg: 150 mg qAM, 300 mg qPM
≥25 kg: 300 mg q12h (OK to start tabs q24h)
Adolescent: 300 mg q12h or 600 mg q24h </td>
         <td class="ped-col-3">600 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Atazanavir (ATV) </td>
      
         <td class="ped-col-2">Neonates: not recommended
Age ≥3 mon, oral powder:
5 to &lt;15 kg: ATV 200 mg &#43; RTV 80 mg q24h
15 to &lt;25 kg: ATV 250 mg &#43; RTV 80 mg q24h
≥25 kg: ATV 300 mg &#43; RTV 100 mg q24h
Age &gt;6 yrs, capsules:
15 to &lt;20 kg: ATV 150 mg &#43; RTV 100 mg q24h
20 to &lt;32 kg: ATV 200 mg &#43; RTV 100 mg q24h
32 to &lt;39 kg: ATV 250 mg &#43; RTV 100 mg q24h
≥39 kg: ATV 300 mg &#43; RTV 100 mg q24h
Adolescents: 400 mg q24h, or 300 mg &#43; RTV 100 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/darunavir"> Darunavir (DRV) </a></td>
      
         <td class="ped-col-2">Neonate: not approved
Age &lt;3 or wt &lt;10 kg: avoid use
Age ≥3 yr, tx naive or exp ± one or more DRV mut:
10 to &lt;11 kg: 200 mg (&#43; RTV 32 mg) q12h
11 to &lt;12 kg: 220 mg (&#43; RTV 32 mg) q12h
12 to &lt;13 kg: 240 mg (&#43; RTV 40 mg) q12h
13 to &lt;14 kg: 260 mg (&#43; RTV 40 mg) q12h
14 to &lt;15 kg: 280 mg (&#43; RTV 48 mg) q12h
15 to &lt;30 kg: 375 mg (&#43; RTV 48 mg) q12h
30 to &lt;40 kg: 450 mg (&#43; RTV 100 mg) q12h
≥40 kg: 600 mg (&#43; RTV 100 mg) q12h
Adolescent:
≥30 to &lt;40 kg, tx exp, ≥1 DRV mut: 450 mg (&#43; RTV 100 mg) q12h
≥40 kg, tx naive/exp, no DRV mut: 800 mg (&#43; RTV 100 mg) q24h
≥40 kg, tx exp, ≥1 DRV mut: 600 mg (&#43; RTV 100 mg) q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Delavirdine (DLV) </td>
      
         <td class="ped-col-2">Safety/efficacy in patients ≤16 years not established </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/didanosine"> Didanosine (ddI) </a></td>
      
         <td class="ped-col-2">Age 2 wk to 3 mon: 50 mg/m2 q12h
Age ≥3 mon to 8 mon: 100 mg/m2 q12h
Age &gt;8 mon: 120 mg/m2 q12h
(240 mg/m2 q24h if age 3-21 yr and tx naive)
EC caps (age 6-18 yr):
20 to &lt;25 kg, 200 mg q24h
25 to &lt;60 kg, 250 mg q24h
≥60 kg, 400 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/dolutegravir"> Dolutegravir (DTG) </a></td>
      
         <td class="ped-col-2">Wt 30 to &lt;40 kg: 35 mg q24h
Wt ≥40 kg: 50 mg q24h
↑ to q12h if given w/EFV, FPV/r, TPV/r, CBZ, rifampin </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/efavirenz"> Efavirenz (EFV) </a></td>
      
         <td class="ped-col-2">Neonates: not approved for use
Age ≥3 yr:
10 to &lt;15 kg, 200 mg q24h
15 to &lt;20 kg, 250 mg q24h
20 to &lt;25 kg, 300 mg q24h
25 to &lt;32.5 kg, 350 mg q24h
32.5 to &lt;40 kg, 400 mg q24h
≥40 kg, 600 mg q24h
Age 3 mon to &lt;3 yr: not recommended
 </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/elvitegravir"> Elvitegravir (EVG) </a></td>
      
         <td class="ped-col-2">As Vitekta, not for use in children age &lt;18 yrs </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/emtricitabine"> Emtricitabine (FTC) </a></td>
      
         <td class="ped-col-2">Oral soln:
0 to ≤3 mon, 3 mg/kg q24h
3 mon to 17 yr: 6 mg/kg (max 240 mg) q24h
≥18 yr, 240 mg q24h
Caps, wt &gt;33 kg: 200 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/enfuvirtide"> Enfuvirtide (T-20) </a></td>
      
         <td class="ped-col-2">Age &lt;6 yrs: not approved for use
Age 6-16 yr: 2 mg/kg (max 90 mg) sc q12h
Age &gt;16 yr: 90 mg sc q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/etravirine"> Etravirine (ETR) </a></td>
      
         <td class="ped-col-2">Age 6-18 yr:
16 to &lt;20 kg, 100 mg q12h
20 to &lt;25 kg, 125 mg q12h
25 to &lt;30 kg, 150 mg q12h
≥30 kg, 200 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Fosamprenavir (FPV) </td>
      
         <td class="ped-col-2">Neonate: use not recommended
Age 2-5 yrs (ARV naive): 30 mg/kg q12h (not recommended)
Age 6 mon to 18 yrs (ARV naive or experienced):
&lt;11 kg: 45 mg/kg q12h (&#43; RTV 7 mg/kg q12h)
11 to &lt;15 kg: 30 mg/kg q12h (&#43; RTV 3 mg/kg q12h)
15 to &lt;20 kg: 23 mg/kg q12h (&#43; RTV 3 mg/kg q12h)
≥20 kg: 18 mg/kg q12h (&#43; RTV 3 mg/kg q12h)
Adolescent, ARV naive:
700 mg q12h (&#43; RTV 100 mg q12h), or
1400 mg q24h (&#43; RTV 100-200 mg q24h)
Adolescent, ARV exp: 700 mg q12h (&#43; RTV 100 mg q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Indinavir (IDV) </td>
      
         <td class="ped-col-2">Neonate/infant: not approved for use
Children: not approved for use
Adolescent: 800 mg q12h (&#43; RTV 100-200 mg q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/lamivudine"> Lamivudine (3TC) </a></td>
      
         <td class="ped-col-2">Oral solution:
Age &lt;4 wks: 2 mg/kg q12h
Age ≥4 wks: 4 mg/kg (max 150 mg) q12h
Tabs:
14 to &lt;20 kg: 75 mg q12h
≥20 to &lt;25 kg: 75 mg qam &#43; 150 mg qpm
≥25 kg: 150 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Maraviroc (MVC) </td>
      
         <td class="ped-col-2">Age ≥2 yrs, w/3A4 inhibitor:
10 to &lt;20 kg: 50 mg q12h (tab or soln)
20 to &lt;30 kg: 80 mg soln q12h or 75 mg tab q12h
30 to &lt;40 kg: 100 mg q12h (tab or soln)
≥40 kg, 150 mg q12h (tab or soln)
Age ≥2 yrs, no interacting meds:
&lt;30 kg: not recommended
≥30 kg: 300 mg q12h (tab or soln)
Age ≥2 yrs, w/3A4 inducer: not recommended </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Nelfinavir (NFV) </td>
      
         <td class="ped-col-2">Neonate (NICHD/HPTN 040/PACTG 1043):
Wt 1.5 to 2 kg: 100 mg q12h
Wt &gt;2 to 3 kg: 150 mg q12h
Wt &gt;3 kg: 200 mg q12h
Age 2-13 yrs: 45-55 mg/kg q12h (8th CROI 2001, #250)
Adolescent: 1250 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Nevirapine (NVP) </td>
      
         <td class="ped-col-2">Neonate, 34-37 wk EGA: 4 mg/kg q12h (no lead-in); increase to 6 mg/kg q12h after one week
Neonate, ≥37 wk EGA to &lt;1 mon: 6 mg/kg q12h (no lead-in)
Neo prophylaxis: 2 mg/kg at birth, 48 hr after dose 1, 96 hr after dose 2
1 mon to &lt;8 yr: 7 mg/kg or 200 mg/m2 q12h
≥8 yr: 4 mg/kg or 120-150 mg/m2 q12h
Adolescent dose: 200 mg q24h x14 days then 200 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/raltegravir"> Raltegravir (RAL) </a></td>
      
         <td class="ped-col-2">Oral susp, age ≥4 weeks:
3 to &lt;4 kg, 20 mg q12h
4 to &lt;6 kg, 30 mg q12h
6 to &lt;8 kg, 40 mg q12h
8 to &lt;11 kg, 60 mg q12h
11 to &lt;14 kg, 80 mg q12h
14 to &lt;20 kg, 100 mg q12h
Chew tab, 2 to &lt;12 yr: 
11 to &lt;14 kg, 75 mg q12h
14 to &lt;20 kg, 100 mg q12h
20 to &lt;28 kg, 150 mg q12h
28 to &lt;40, 200 mg q12h
≥40 kg, 300 mg q12h
Film-coated tab:
≥25 kg: 400 mg q12h
≥40 kg, tx-naive or suppr on 400 mg q12h: 1200 mg q24h
Neonates (invest), ≥37 wks gestation, wt ≥2 kg
Birth to 7 days: 1.5 mg/kg q24h
8 days to 28 days: 3 mg/kg q12h
≥4 weeks: 6 mg/kg q12h (see above) </td>
         <td class="ped-col-3">2h   </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/rilpivirine"> Rilpivirine (RPV) </a></td>
      
         <td class="ped-col-2">Adolescent ≥12 yrs, ≥35 kg: 25 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Ritonavir (RTV) </td>
      
         <td class="ped-col-2">Neonates: dose not established
Peds dose: 350-400 mg/m2 q12h (not recommended)
Used as pharmacologic enhancer </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Saquinavir (SQV) </td>
      
         <td class="ped-col-2">Neonate/infant: not approved for use
Age &lt;2 yrs: dose not determined
Age ≥2 yrs:
Wt 5 to &lt;15 kg: 50 mg/kg q12h (&#43;RTV 3 mg/kg q12h)
Wt 15 to &lt;40 kg: 50 mg/kg q12h (&#43;RTV 2.5 mg/kg q12h)
Wt ≥40 kg: 50 mg/kg q12h (&#43;RTV 100 mg q12h)
Adolescent (age ≥16 yrs): 1 gm q12h (&#43;RTV 100 mg q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/stavudine"> Stavudine (d4T) </a></td>
      
         <td class="ped-col-2">Age 0-13 days: 0.5 mg/kg q12h
Age ≥14 days, &lt;30 kg: 1 mg/kg q12h
≥30 kg: 30 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Tenofovir alafenamide (TAF) </td>
      
         <td class="ped-col-2">≥12 yrs, wt ≥35 kg:
10 mg q24h (part of Genvoya)
25 mg q24h (part of Descovy, Odefsey)
Vemlidy not approved for patients &lt;18 yrs of age </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/tenofovir-disproxil-fumarate"> Tenofovir (TDF) </a></td>
      
         <td class="ped-col-2">Age 2 to &lt;12 yr:
8 mg/kg powder (max 300 mg) q24h [1 scoop=40 mg]
Tablets, weight-based:
17 to &lt;22 kg: 150 mg q24h
22 to &lt;28 kg: 200 mg q24h
28 to &lt;35 kg: 250 mg q24h
≥35 kg: 300 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Tipranavir (TPV) </td>
      
         <td class="ped-col-2">Age &lt;2 yrs: use not approved
Age ≥2 to 18 yrs:
by BSA: 375 mg/m2 q12h (&#43;RTV 150 mg/m2 q12h)
by wt: 14 mg/kg q12h (&#43;RTV 6 mg/kg q12h)
(not recommended for tx naive pts)
Adolescent: 500 mg q12h (&#43;RTV 200 mg q12h)
(not recommended for tx naive pts) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/zidovudine"> Zidovudine (ZDV) </a></td>
      
         <td class="ped-col-2">Neonate, EGA &lt;30 wks:
age 0-4 weeks: 2 mg/kg po q12h or 1.5 mg/kg IV q12h
(increase to 3 mg/kg po q12h at age 4 weeks)
Neonate, EGA ≥30 to &lt;35 wks:
age 0-2 weeks: 2 mg/kg po q12h or 1.5 mg/kg IV q12h
(increase to 3 mg/kg po q12h at age 2 weeks)
EGA ≥35 wks, age 0-4 wks: 4 mg/kg q12h or 1.5 mg/kg IV q6h
Infant/child (EGA ≥35 wks, age ≥4 wks):
4 to &lt;9 kg: 12 mg/kg po q12h
9 to &lt;30 kg: 9 mg/kg po q12h
≥30 kg: 300 mg q12h
Dosing by BSA: 180-240 mg/m2 po q12h
Adolescent: 300 mg po q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antiretroviral combination products </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Atripla (EFV/FTC/TDF) </td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥40 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Combivir (3TC/AZT) </td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥30 kg: one tab q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Complera (RPV/FTC/TDF) </td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Descovy (FTC/TAF) </td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Epzicom (ABC/3TC) </td>
      
         <td class="ped-col-2">Wt ≥25 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Evotaz (ATV/cobi) </td>
      
         <td class="ped-col-2">Age &lt;18: not recommended </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/genvoya"> Genvoya (EVG/cobi/FTC/TAF) </a></td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Kaletra (LPV/RTV) </td>
      
         <td class="ped-col-2">Age &lt;14 days: avoid use
Age 14 days to 12 mon: 300 mg/75 mg per m2 q12h
Age &gt;12 mon to 18 yrs:
300 mg/75 mg per m2 q12h (tx-experienced)
230 mg/57.5 mg per m2 q12h (tx-naive) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Odefsey (RPV/FTC/TAF) </td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Prezcobix (DRV/cobi) </td>
      
         <td class="ped-col-2">Age &lt;18: not recommended </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/stribild"> Stribild (EVG/cobi/FTC/TDF) </a></td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Triumeq (DTG/ABC/3TC) </td>
      
         <td class="ped-col-2">Wt ≥40 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Trizivir (ABC/3TC/ZDV) </td>
      
         <td class="ped-col-2">Wt ≥40 kg: one tab q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/truvada"> Truvada (FTC/TDF) </a></td>
      
         <td class="ped-col-2">Wt 17 to &lt;22 kg: 100 mg/150 mg q24h
Wt 22 to &lt;28 kg: 133 mg/200 mg q24h
Wt 28 to &lt;35 kg: 167 mg/250 mg q24h
Wt ≥35 kg: 200 mg/300 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antivirals </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) neonatal herpes simplex </a></td>
      
         <td class="ped-col-2">60 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) HSV encephalitis &gt;3 months </a></td>
      
         <td class="ped-col-2">30-45 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) varicella immunocompromised </a></td>
      
         <td class="ped-col-2">&lt;1 year: 30 mg/kg/day (divided q8h)
&gt;1 year: 30 mg/kg/day or 1500 mg/m2/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) HSV immunocompromised </a></td>
      
         <td class="ped-col-2">30 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/cidofovir"> Cidofovir </a></td>
      
         <td class="ped-col-2">Induction 5 mg/kg once weekly
Suppressive therapy 3 mg/kg once weekly
(all with hydration &#43; probenecid) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/entecavir"> Entecavir (treatment-naive) </a></td>
      
         <td class="ped-col-2">Wt 10-11 kg, 0.15 mg q24h
&gt;11 to 14 kg, 0.2 mg q24h
&gt;14 to 17 kg, 0.25 mg q24h
&gt;17 to 20 kg, 0.3 mg q24h
&gt;20 to 23 kg, 0.35 mg q24h
&gt;23 to 26 kg, 0.4 mg q24h
&gt;26 to 30 kg, 0.45 mg q24h
&gt;30 kg, 0.5 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/entecavir"> Entecavir (lamivudine-experienced) </a></td>
      
         <td class="ped-col-2">Wt 10-11 kg, 0.3 mg q24h
&gt;11 to 14 kg, 0.4 mg q24h
&gt;14 to 17 kg, 0.5 mg q24h
&gt;17 to 20 kg, 0.6 mg q24h
&gt;20 to 23 kg, 0.7 mg q24h
&gt;23 to 26 kg, 0.8 mg q24h
&gt;26 to 30 kg, 0.9 mg q24h
&gt;30 kg, 1 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/foscarnet"> Foscarnet </a></td>
      
         <td class="ped-col-2">120-180 mg/kg/day (divided q8-12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/ganciclovir"> Ganciclovir </a></td>
      
         <td class="ped-col-2">Symptomatic congenital CMV 12 mg/kg/day (divided q12h)
CMV tx or first 2 weeks after SOT: 10 mg/kg/day (divided q12h)
Suppressive tx or prophylaxis 5 mg/kg/day (divided q24h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Glecaprevir/pibrentasvir (Mavyret) </td>
      
         <td class="ped-col-2">Age &lt;18: safety and effectiveness not established </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Ledipasvir/sofosbuvir (Harvoni) </td>
      
         <td class="ped-col-2">Age ≥12 yrs or ≥35 kg: 1 tab q24h
Geno 1, tx-naive, no cirr or comp: 12 wks
Geno 1, tx-exp, no cirr=12 wks
Geno 1, tx-exp with comp=24 wks
Geno 4/5/6, tx-naive/exp, no cirr or comp=12 wks
 </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/oseltamivir"> Oseltamivir &lt;1 year old </a></td>
      
         <td class="ped-col-2">6 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/oseltamivir"> Oseltamivir ≥1 year old </a></td>
      
         <td class="ped-col-2">&lt;15 kg: 30 mg bid
&gt;15 to 23 kg: 45 mg bid
&gt;23 to 40 kg: 60 mg bid
&gt;40 kg: 75 mg bid (adult dose) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/peramivir"> Peramivir </a></td>
      
         <td class="ped-col-2">Not studied </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Ribavirin (with sofosbuvir) </td>
      
         <td class="ped-col-2">Wt &lt;47 kg: 15 mg/kg/day
47-49 kg: 600 mg/day
50-65 kg: 800 mg/day
66-80 kg: 1000 mg/day
&gt;80 kg: 1200 mg/day (all doses divided bid) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Sofosbuvir </td>
      
         <td class="ped-col-2">Age ≥12 yrs or ≥35 kg: 400 mg (1 tab) q24h
Geno 2, tx-naive/exp, no cirr or comp=12 wks (with ribavirin)
Geno 3, tx-naive/exp, no cirr or comp=24 wks (with ribavirin). </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/valacyclovir"> Valacyclovir (Varicella or Herpes Zoster) </a></td>
      
         <td class="ped-col-2">60 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">3 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/valganciclovir"> Valganciclovir </a></td>
      
         <td class="ped-col-2">Symptomatic congenital CMV: 32 mg/kg/day (divided q12h)
Prevention of CMV after SOT: 7 mg x BSA x CrCl
(once daily; use Schwartz formula for CrCl). </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/zanamavir"> Zanamivir (age &gt;7 years) </a></td>
      
         <td class="ped-col-2">10 mg (two 5-mg inhalations) q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1">  </td>
      
         <td class="ped-col-2"> </td>
         <td class="ped-col-3">  </td>
       </tr>
     </table>
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