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        loadEditorNoteModal("There are limited data on when to switch adolescents to adult dosing. In general, pediatric weight based dosing is appropriate through mid puberty \(Tanner 3\) if no maximum dose is specified. Some change to adult dosing at 40 kg. If in doubt, when treating serious infections in peri-pubertal adolescents with drugs that have large margins of safety \(e.g. Beta lactams and carbapenems\) it may be safer to err on the side of higher doses."); 
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  <title>Pediatric Dosing</title>
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    <div id="xsTitle" class="tableTitle visible-xs"  style="visibility:hidden">Pediatric Dosing</div>
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 <div class="dataTable">
   <div class="fixedHeaders">
        <table class="mainTableHeaders">
          <thead>
            <tr class="tableHeader">
              <td class="colHeader ped-col-1"> <br/>Drug </td>
              <td class="colHeader ped-col-2"> Dose<br/>(Age >28 Days)</td>
              <td class="colHeader ped-col-3"> <br/>Max/Day</td>
            </tr>
          </thead>
        </table>
      </div>
   <div class="dataRows">
     <table class="mainTable" id="mainTable">
    
      
       <tr class="drugFamily">
         <td colspan="3"><b> Antibacterials </b></td>
       </tr>
    
      
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/aminoglycosides-overview">Aminoglycosides</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/amikacin"> Amikacin </a></td>
      
         <td class="ped-col-2">15-20 mg/kg/day (once daily);  
15-22.5 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/gentamicin"> Gentamicin </a></td>
      
         <td class="ped-col-2">5-7 mg/kg/day once daily; 
2.5 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/tobramycin"> Tobramycin </a></td>
      
         <td class="ped-col-2">5-7 mg/kg/day once daily; 
2.5 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/comparisons-1/adverse-effects/penicillin-beta-lactam-allergy">Beta-Lactams</a></td>
       </tr>

      
       <tr class="drugSubClass">
         <td colspan="3"> Carbapenems </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/carbapenems/ertapenem"> Ertapenem </a></td>
      
         <td class="ped-col-2">30 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/carbapenems/imipenem-cilastatin"> Imipenem </a></td>
      
         <td class="ped-col-2">60-100 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">2-4 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/carbapenems/meropenem"> Meropenem </a></td>
      
         <td class="ped-col-2">60 mg/kg/day (divided q8h); 
Meningitis: 120 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugSubClass">
         <td colspan="3"> Cephalosporins (po) </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/cefaclor"> Cefaclor </a></td>
      
         <td class="ped-col-2">20-40 mg/kg/day (divided q8-12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/1st-generation/cefadroxil"> Cefadroxil </a></td>
      
         <td class="ped-col-2">30 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/cefdinir"> Cefdinir </a></td>
      
         <td class="ped-col-2">14 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/cefixime"> Cefixime </a></td>
      
         <td class="ped-col-2">8 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/cefpodoxime-proxetil"> Cefpodoxime </a></td>
      
         <td class="ped-col-2">10 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">400 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/cefprozil"> Cefprozil </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (divided q12h) -- use 30 for AOM </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/3rd-generation/ceftibuten"> Ceftibuten </a></td>
      
         <td class="ped-col-2">9 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/cefuroxime-axetil"> Cefuroxime axetil </a></td>
      
         <td class="ped-col-2">20-30 mg/kg/day (divided q12h) -- use 30 for AOM </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/1st-generation/cephalexin"> Cephalexin </a></td>
      
         <td class="ped-col-2">25-100 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">4 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/oral/2nd-generation/loracarbef"> Loracarbef </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">800 mg  </td>
       </tr>
       <tr class="drugSubClass">
         <td colspan="3"> Cephalosporins (IV) </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/1st-generation/cefazolin"> Cefazolin </a></td>
      
         <td class="ped-col-2">50-150 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/cefepime"> Cefepime (non-Pseudomonal) </a></td>
      
         <td class="ped-col-2">100 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/cefepime"> Cefepime (Pseudomonal) </a></td>
      
         <td class="ped-col-2">150 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/cefotaxime"> Cefotaxime </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6-8h); 
Meningitis: 300 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/2nd-generation/cefotetan"> Cefotetan </a></td>
      
         <td class="ped-col-2">60-100 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/2nd-generation/cefoxitin"> Cefoxitin </a></td>
      
         <td class="ped-col-2">80-160 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftaroline"> Ceftaroline </a></td>
      
         <td class="ped-col-2">2 mon to &lt;2 yrs, 8 mg/kg q8h; ≥2 yrs to &lt;18 yrs: if ≤33 kg, 12 mg/kg q8h; if &gt;33 kg: 400 mg q8h or 600 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftazidime-avibactam"> Ceftazidime </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q8h); 
CF: 300 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftizoxime"> Ceftizoxime </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/3rd-4th-generation/ceftriaxone"> Ceftriaxone </a></td>
      
         <td class="ped-col-2">50-100 mg/kg q24h; 
Meningitis: 50 mg/kg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/cephalosporins/parenteral/2nd-generation/cefuroxime"> Cefuroxime </a></td>
      
         <td class="ped-col-2">150 mg/kg/day (divided q8h); 
Meningitis: 80 mg/kg q8h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugSubClass">
         <td colspan="3"> Penicillins </td>
       </tr>

       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin"> Amoxicillin </a></td>
      
         <td class="ped-col-2">25-50 mg/kg/day (divided q8h)  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin"> Amoxicillin (AOM, pneumonia) </a></td>
      
         <td class="ped-col-2">80-100 mg/kg/day (divided q8-12h,
q12h for AOM) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin-clavulanate"> Amoxicillin-clavulanate 7:1 formulation </a></td>
      
         <td class="ped-col-2">45 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/amoxicillin-clavulanate"> Amoxicillin-clavulanate 14:1  (AOM) </a></td>
      
         <td class="ped-col-2">90 mg/kg/day (divided q12h) for wt &lt;40 kg </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/ampicillin"> Ampicillin (IV) </a></td>
      
         <td class="ped-col-2">200 mg/kg/day (divided q6h); 
Meningitis: 300-400 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/amino-penicillins/ampicillin-sulbactam"> Ampicillin-sulbactam </a></td>
      
         <td class="ped-col-2">100-300 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/cloxacillin"> Cloxacillin (PO) </a></td>
      
         <td class="ped-col-2">If &lt;20 kg: 25-50 mg/kg/day (divided q6h)
Otherwise dose as adult </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/dicloxacin"> Dicloxacillin (mild - moderate) </a></td>
      
         <td class="ped-col-2">12.5-25 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/dicloxacin"> Dicloxacillin (osteo articular infection) </a></td>
      
         <td class="ped-col-2">100 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/flucloxacin"> Flucloxacillin </a></td>
      
         <td class="ped-col-2">Age 2-10: 50% of adult dose; 
Age&lt;2: 25% of adult dose </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/nafcillin"> Nafcillin </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/antistaphylo-coccal-penicillins/oxacillin"> Oxacillin </a></td>
      
         <td class="ped-col-2">150-200 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/penicillin-g"> Penicillin G </a></td>
      
         <td class="ped-col-2">150,000-300,000 units/kg/day (divided q4-6h) </td>
         <td class="ped-col-3">12-20 million units  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/penicillin-v"> Penicillin VK </a></td>
      
         <td class="ped-col-2">25-75 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/anti-pseudomonal-penicillins/piperacillin-tazobactam"> Piperacillin-tazobactam </a></td>
      
         <td class="ped-col-2">300 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/penicillins/temocillin"> Temocillin </a></td>
      
         <td class="ped-col-2">25 mg/kg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/fluoroquinolones-overview">Fluoroquinolones</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/ciprofloxacin"> Ciprofloxacin (PO) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Approved only for CF, anthrax, and complicated UTI" data-header="Ciprofloxacin (PO)">20-40 mg/kg/day (divided q12h) <span class="supascript">*</span></a></td>
         <td class="ped-col-3">1.5 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/ciprofloxacin"> Ciprofloxacin (IV) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Approved only for CF, anthrax, and complicated UTI" data-header="Ciprofloxacin (IV)">20-30 mg/kg/day (divided q12h) <span class="supascript">*</span></a></td>
         <td class="ped-col-3">1.2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fluoroquinolones/levofloxacin"> Levofloxacin (IV/PO) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Approved only for CF, anthrax, and complicated UTI" data-header="Levofloxacin (IV/PO)">16-20 mg/kg/day (divided q12h) <span class="supascript">*</span></a></td>
         <td class="ped-col-3">750 mg  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Lincosamides</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/clindamycin-1/clindamycin"> Clindamycin (PO) </a></td>
      
         <td class="ped-col-2">30-40 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/clindamycin-1/clindamycin"> Clindamycin (IV) </a></td>
      
         <td class="ped-col-2">20-40 mg/kg/day (divided q6-8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/clindamycin-1/lincomycin"> Lincomycin </a></td>
      
         <td class="ped-col-2">10-20 mg/kg/day (divided q8-12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Lipopeptides</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/glyco-lipoglyco-peptides/daptomycin"> Daptomycin </a></td>
      
         <td class="ped-col-2">6-10 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/macrolides-overview">Macrolides</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/azithromycin"> Azithromycin (po) </a></td>
      
         <td class="ped-col-2">5-12 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/azithromycin"> Azithromycin (IV) </a></td>
      
         <td class="ped-col-2">10 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/clarithromycin"> Clarithromycin </a></td>
      
         <td class="ped-col-2">15 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/macrolides/erythromycin-base-esters"> Erythromycin (po, IV) </a></td>
      
         <td class="ped-col-2">40-50 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Monobactams</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/monobactam/aztreonam"> Aztreonam </a></td>
      
         <td class="ped-col-2">90-120 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">8 gm  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/tetracycline">Tetracyclines</a></td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/doxycycline"> Doxycycline (po/IV, age &gt;8 yrs) </a></td>
      
         <td class="ped-col-2">2-4 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">200 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/minocycline"> Minocycline (PO, age &gt;8) </a></td>
      
         <td class="ped-col-2">4 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/tetra-cyclines/tetracycline"> Tetracycline </a></td>
      
         <td class="ped-col-2">Age &gt;8: 25-50 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="drugClass">
         <td colspan="3">Other</td>
       </tr>

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/chloramphenicol"> Chloramphenicol (IV) </a></td>
      
         <td class="ped-col-2">50-100 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">2-4 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/polymyxins/polymyxin-e-colistin"> Colistin </a></td>
      
         <td class="ped-col-2">2.5-5 mg/kg/day (divided q6-12h);
CF: 3-8 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/fosfomycin"> Fosfomycin (PO) </a></td>
      
         <td class="ped-col-2">2 gm once </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/fusidanes/fusidic-acid"> Fusidic acid (PO) </a></td>
      
         <td class="ped-col-2">Age 1-5: 250 mg q8h; 
Age 6-12: 250-500 mg q8h  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/oxazolidinones/linezolid-zyvox"> Linezolid (up to age 12 yrs) </a></td>
      
         <td class="ped-col-2">30 mg/kg/day IV/po (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/methenamine-hippurate"> Methenamine hippurate (age 6-12) </a></td>
      
         <td class="ped-col-2">500-1000 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/methenamine-hippurate"> Methenamine mandelate </a></td>
      
         <td class="ped-col-2">Age &gt;2 to 6: 50-75 mg/kg/day (divided q6-8h); 
Age 6-12: 500 mg q6h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/nitroimidazoles/metronidazole"> Metronidazole (PO) </a></td>
      
         <td class="ped-col-2">30-40 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/nitroimidazoles/metronidazole"> Metronidazole (IV) </a></td>
      
         <td class="ped-col-2">22.5-40 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/nitrofurantoin"> Nitrofurantoin (PO Cystitis) </a></td>
      
         <td class="ped-col-2">5-7 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/agents-urinary-tract/nitrofurantoin"> Nitrofurantoin (PO UTI prophylaxis) </a></td>
      
         <td class="ped-col-2">1-2 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/polymyxins/polymixin-b"> Polymyxin B (age 2 and older) </a></td>
      
         <td class="ped-col-2">2.5 mg/kg (load), then 1.5 mg/kg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifampin"> Rifampin (meningococcal prophylaxis) </a></td>
      
         <td class="ped-col-2">10 mg/kg q12h x2 days </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/nitroimidazoles/tinidazole"> Tinidazole (age &gt;3 for Giardia, amebiasis) </a></td>
      
         <td class="ped-col-2">50 mg/kg q24h x1-5 days </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiparasitic-agents/sulfadiazine"> Sulfadiazine </a></td>
      
         <td class="ped-col-2">120-150 mg/kg/day (divided q4-6h) </td>
         <td class="ped-col-3">6 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/trimethoprim-sulfonamides/trimethoprim-sulfamethoxazole"> TMP-SMX (UTI and other)  </a></td>
      
         <td class="ped-col-2"> 8-12 mg TMP/kg/day (divided q12h)  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/trimethoprim-sulfonamides/trimethoprim-sulfamethoxazole"> TMP-SMX (PCP) </a></td>
      
         <td class="ped-col-2">15-20 mg TMP/kg/day (divided q12h)  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/trimethoprim-sulfonamides/trimethoprim"> Trimethoprim </a></td>
      
         <td class="ped-col-2">4 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/glyco-lipoglyco-peptides/vancomycin"> Vancomycin (IV) </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Use serum concentration to target trough 10-15 mcg/mL; 60 mg/kg/day most likely to achieve target" data-header="Vancomycin (IV)">40-60 mg/kg/day (divided q6-8h)<span class="supascript">*</span></a></td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/glyco-lipoglyco-peptides/vancomycin"> Vancomycin (PO for C. difficile) </a></td>
      
         <td class="ped-col-2">40 mg/kg/day (divided q6h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antimycobacterials </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/capreomycin-sulfate"> Capreomycin </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/cycloserine"> Cycloserine </a></td>
      
         <td class="ped-col-2">10-15 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/ethambutol"> Ethambutol </a></td>
      
         <td class="ped-col-2">15-25 mg/kg/day (once daily) </td>
         <td class="ped-col-3">2.5 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/ethionamide"> Ethionamide </a></td>
      
         <td class="ped-col-2">15-20 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/isoniazid"> Isoniazid (daily dosing) </a></td>
      
         <td class="ped-col-2">10-15 mg/kg/day (once daily) </td>
         <td class="ped-col-3">300 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/isoniazid"> Isoniazid (2 x/week) </a></td>
      
         <td class="ped-col-2">20-30 mg/kg twice weekly </td>
         <td class="ped-col-3">900 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/kanamycin"> Kanamycin </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (once daily) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/para-aminosalicylic-acid"> Para-aminosalicylic acid </a></td>
      
         <td class="ped-col-2">200-300 mg/kg/day (divided q6-12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/pyrazinamide"> Pyrazinamide (daily) </a></td>
      
         <td class="ped-col-2">15-30 mg/kg/day (once daily) </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/pyrazinamide"> Pyrazinamide (2 x/week) </a></td>
      
         <td class="ped-col-2">50 mg/kg twice weekly </td>
         <td class="ped-col-3">2 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifabutin"> Rifabutin (MAC prophylaxis) </a></td>
      
         <td class="ped-col-2">5 mg/kg/day (once daily) </td>
         <td class="ped-col-3">300 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifabutin"> Rifabutin (active TB) </a></td>
      
         <td class="ped-col-2">10-20 mg/kg/day (once daily) </td>
         <td class="ped-col-3">300 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antimycobacterial-agents/rifampin"> Rifampin </a></td>
      
         <td class="ped-col-2">10-20 mg/kg/day (divided q12-24h) </td>
         <td class="ped-col-3">600 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antibacterial-agents/amino-glycosides/streptomycin"> Streptomycin (age 2 and older) </a></td>
      
         <td class="ped-col-2">20-40 mg/kg/day (once daily) </td>
         <td class="ped-col-3">1 gm  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antifungals </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/amphotericin-b"> Amphotericin B deoxycholate </a></td>
      
         <td class="ped-col-2">0.5-1 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/amphotericin-b"> Amphotericin B lipid complex </a></td>
      
         <td class="ped-col-2">5 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/anidulafungin"> Anidulafungin </a></td>
      
         <td class="ped-col-2">1.5-3 mg/kg loading dose, then 0.75-1.5 mg/kg/day (once daily) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/caspofungin"> Caspofungin </a></td>
      
         <td class="ped-col-2">70 mg/m2 loading dose, then 50 mg/m2 (once daily) </td>
         <td class="ped-col-3">70 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/fluconazole"> Fluconazole </a></td>
      
         <td class="ped-col-2">6 mg/kg/day for oral/esophageal Candida,
12 mg/kg/day for invasive disease </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/isavuconazole"> Isavuconazole </a></td>
      
         <td class="ped-col-2">Not established </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/itraconazole"> Itraconazole </a></td>
      
         <td class="ped-col-2">5-10 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">600 mg  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/ketoconazole"> Ketoconazole </a></td>
      
         <td class="ped-col-2">3.3-6.6 mg/kg/day (once daily) </td>
         <td class="ped-col-3">400 mg  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/micafungin"> Micafungin </a></td>
      
         <td class="ped-col-2">Age &gt;4 mon: 2 mg/kg q24h (max 100 mg) for candidiasis; for EC use 3 mg/kg q24h if &lt;30 kg, 2.5 mg/kg q24h (max 150 mg) if &gt;30 kg </td>
         <td class="ped-col-3">See dose  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/posaconazole"> Posaconazole </a></td>
      
         <td class="ped-col-2">Age 13-17: safety and efficacy of oral susp and tabs (but not injection) established. Use adult dose. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/terbinafine"> Terbinafine </a></td>
      
         <td class="ped-col-2">&lt;25 kg 125 mg/day;
25-35 kg 187.5 mg/day;
&gt;35 kg 250 mg/day (adult dose) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antifungal-agents/voriconazole"> Voriconazole </a></td>
      
         <td class="ped-col-2"><a class="tableLink" href="#" data-toggle="modal" data-target="#tooltipModal" data-tooltip="Variable bioavailabilty and metabolism. Adjust to trough level 1-6 mcg/mL                                        " data-header="Voriconazole">12-20 mg/kg/day (divided q12h)<span class="supascript">*</span></a></td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antiretrovirals </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/abacavir"> Abacavir (ABC) </a></td>
      
         <td class="ped-col-2">Oral soln, age ≥3 mon: 8 mg/kg q12h, or 16 mg/kg q24h (max 600 mg/day). Start soln q12h. Tabs, wt-based: 14 to &lt;20 kg, 150 mg q12h; ≥20 to &lt;25 kg, 150 mg qAM, 300 mg qPM; ≥25 kg, 300 mg q12h. OK to start tabs q24h. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/darunavir"> Darunavir (DRV) </a></td>
      
         <td class="ped-col-2">Age 3 to &lt;12 yr: 10 to &lt;11 kg, 200 mg &#43; RTV 32 mg q12h; 11 to &lt;12 kg, 220 mg &#43; RTV 32 mg q12h; 12 to &lt;13 kg, 240 mg &#43; RTV 40 mg q12h; 13 to &lt;14 kg, 260 mg &#43; RTV 40 mg q12h; 14 to &lt;15 kg, 280 mg &#43; RTV 48 mg q12h; 15 to &lt;30 kg, 375 mg &#43; RTV 48 mg q12h; 30 to &lt;40 kg, 450 mg &#43; RTV 100 mg q12h; ≥40 kg, 600 mg &#43; RTV 100 mg q12h  </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/didanosine"> Didanosine (ddI) </a></td>
      
         <td class="ped-col-2">Age 2 wk to 3 mon: 50 mg/m2 q12h. ≥3 mon to 8 mon: 100 mg/m2 q12h. &gt;8 mon: 120 mg/m2 q12h (240 mg/m2 q24h if age 3-21 yr and tx naive). EC caps (age 6-18 yr): wt 20 to &lt;25 kg, 200 mg q24h; 25 to &lt;60 kg, 250 mg q24h; ≥60 kg, 400 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/dolutegravir"> Dolutegravir (DTG) </a></td>
      
         <td class="ped-col-2">Age 6 to &lt;12 yr, wt 30 to &lt;40 kg: 35 mg q24h; wt ≥40 kg: 50 mg q24h. Increase to q12h if given with EFV, FPV/r, TPV/r, carbamazepine, or rifampin </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/efavirenz"> Efavirenz (EFV) </a></td>
      
         <td class="ped-col-2">Age ≥3 yr: 10 to &lt;15 kg, 200 mg q24h; 15 to &lt;20 kg, 250 mg q24h; 20 to &lt;25 kg, 300 mg q24h; 25 to &lt;32.5 kg, 350 mg q24h; 32.5 to &lt;40 kg, 400 mg q24h; ≥40 kg, 600 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/elvitegravir"> Elvitegravir (EVG) </a></td>
      
         <td class="ped-col-2">As Vitekta, not for use in children age &lt;18 yrs </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/emtricitabine"> Emtricitabine (FTC) </a></td>
      
         <td class="ped-col-2">Oral soln: age 0 to &lt;3 mon, 3 mg/kg q24h; 3 mon to 17 yr: 6 mg/kg (max 240 mg) q24h; ≥18 yr, 240 mg q24h. Caps: wt &gt;33 kg, 200 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/enfuvirtide"> Enfuvirtide (T-20) </a></td>
      
         <td class="ped-col-2">Age 6-16 yr: 2 mg/kg (max 90 mg) sc q12h; &gt;16 yr: 90 mg sc q12h. Not approved for age &lt;6 </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/etravirine"> Etravirine (ETR) </a></td>
      
         <td class="ped-col-2">Age 6-18 yr: Wt 16 to &lt;20 kg, 100 mg q12h; 20 to &lt;25 kg, 125 mg q12h; 25 to &lt;30 kg, 150 mg q12h; ≥30 kg, 200 mg q12h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/lamivudine"> Lamivudine (3TC) </a></td>
      
         <td class="ped-col-2">Age &lt;4 wks: 2 mg/kg q12h. ≥4 wks: 4 mg/kg (max 150 mg) q12h. Tabs: Wt 14 to &lt;20 kg, 75 mg q12h; ≥20 to &lt;25 kg, 75 mg qam &#43; 150 mg qpm; ≥25 kg, 150 mg q12h. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Maraviroc (MVC) </td>
      
         <td class="ped-col-2">Oral soln, age ≥2 yrs, w/3A4 inhibitor: 10 to &lt;20 kg, 50 mg q12h; 20 to &lt;30 kg, 75 mg q12h; 30 to &lt;40 kg, 100 mg q12h; ≥40 kg, 150 mg q12h. No interacting meds: &lt;30 kg, not recommended; ≥30 kg, 300 mg q12h. With 3A4 inducer: not recommended. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/raltegravir"> Raltegravir (RAL) </a></td>
      
         <td class="ped-col-2">Oral susp, age ≥4 weeks: 3 to &lt;4 kg, 20 mg q12h; 4 to &lt;6 kg, 30 mg q12h; 6 to &lt;8 kg, 40 mg q12h; 8 to &lt;11 kg, 60 mg q12h; 11 to &lt;14 kg, 80 mg q12h; 14 to &lt;20 kg, 100 mg q12h. Chew tab, 2 to &lt;12 yr: 11 to &lt;14 kg, 75 mg q12h; 14 to &lt;20 kg, 100 mg q12h; 20 to &lt;28 kg, 150 mg q12h; 28 to &lt;40, 200 mg q12h; ≥40 kg, 300 mg q12h. Age ≥12: 400 mg film-coated tab q12h. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/rilpivirine"> Rilpivirine (RPV) </a></td>
      
         <td class="ped-col-2">Adolescent, ≥35 kg: 25 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/stavudine"> Stavudine (d4T) </a></td>
      
         <td class="ped-col-2">Age 0-13 days: 0.5 mg/kg q12h. ≥14 days, &lt;30 kg: 1 mg/kg q12h. ≥30 kg: 30 mg q12h. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/tenofovir-disproxil-fumarate"> Tenofovir (TDF) </a></td>
      
         <td class="ped-col-2">Age 2 to &lt;12 yr: 8 mg/kg powder (max 300 mg) q24h [1 scoop=40 mg]. Tabs (age ≥2 yr): 17 to &lt;22 kg: 150 mg q24h; 22 to &lt;28 kg: 200 mg q24h; 28 to &lt;35 kg: 250 mg q24h; ≥35 kg: 300 mg q24h. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/zidovudine"> Zidovudine (ZDV) </a></td>
      
         <td class="ped-col-2">Neonate, EGA &lt;30 wk: age 0-4 wk, 2 mg/kg q12h; 4-8 wk, 3 mg/kg q12h; &gt;8 to 10 wk. 12 mg/kg q12h. EGA ≥30 to &lt;35 wk: age 0-2 wk, 2 mg/kg q12h; 2-6 wk, 3 mg/kg q12h; &gt;6 to 8 wk, 12 mg/kg q12h. EGA ≥35 wk: age 0-4 wk: 4 mg/kg q12h; ≥4 wk po: 4 to &lt;9 kg, 12 mg/kg q12h; 9 to &lt;30 kg, 9 mg/kg q12h; ≥30 kg, 300 mg q12h. IV dose=75% of po, same interval. By BSA: 180-240 mg/m2 po q12h. Adolescent: 300 mg po q12h. </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antiretroviral combination products </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/genvoya"> Genvoya (EVG/cobi/FTC/TAF) </a></td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/stribild"> Stribild (EVG/cobi/FTC/TDF) </a></td>
      
         <td class="ped-col-2">Age ≥12 yr, wt ≥35 kg: one tab q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiretroviral-agents/truvada"> Truvada (FTC/TDF) </a></td>
      
         <td class="ped-col-2">Wt 17 to &lt;22 kg, 100/150 mg q24h; 22 to &lt;28 kg, 133/200 mg q24h; 28 to &lt;35 kg, 167/250 mg q24h; ≥35 kg, 200/300 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="drugFamily">
         <td colspan="3"><b> Antivirals </b></td>
       </tr>
    
      

      
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) neonatal herpes simplex </a></td>
      
         <td class="ped-col-2">60 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) HSV encephalitis &gt;3 months </a></td>
      
         <td class="ped-col-2">30-45 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) varicella immunocompromised </a></td>
      
         <td class="ped-col-2">&lt;1 year 30 mg/kg/day (divided q8h); 
&gt;1 year 30 mg/kg/day or 1500 mg/M2/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/acyclovir"> Acyclovir (IV) HSV immunocompromised </a></td>
      
         <td class="ped-col-2">30 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/cidofovir"> Cidofovir </a></td>
      
         <td class="ped-col-2">Induction 5 mg/kg once weekly;
Suppressive therapy 3 mg/kg once weekly (all with hydration and probenecid) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/entecavir"> Entecavir (treatment-naive) </a></td>
      
         <td class="ped-col-2">Wt 10-11 kg, 0.15 mg q24h; &gt;11 to 14 kg, 0.2 mg q24h; &gt;14 to 17 kg, 0.25 mg q24h; &gt;17 to 20 kg, 0.3 mg q24h; &gt;20 to 23 kg, 0.35 mg q24h; &gt;23 to 26 kg, 0.4 mg q24h; &gt;26 to 30 kg, 0.45 mg q24h; &gt;30 kg, 0.5 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/entecavir"> Entecavir (lamivudine-experienced) </a></td>
      
         <td class="ped-col-2">Wt 10-11 kg, 0.3 mg q24h; &gt;11 to 14 kg, 0.4 mg q24h; &gt;14 to 17 kg, 0.5 mg q24h; &gt;17 to 20 kg, 0.6 mg q24h; &gt;20 to 23 kg, 0.7 mg q24h; &gt;23 to 26 kg, 0.8 mg q24h; &gt;26 to 30 kg, 0.9 mg q24h; &gt;30 kg, 1 mg q24h </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/foscarnet"> Foscarnet </a></td>
      
         <td class="ped-col-2">120-180 mg/kg/day (divided q8-12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/ganciclovir"> Ganciclovir </a></td>
      
         <td class="ped-col-2">Symptomatic congenital CMV 12 mg/kg/day (divided q12h);
CMV treatment or first 2 weeks after SOT 10 mg/kg/day (divided q12h);
Suppressive therapy or prophylaxis 5 mg/kg/day (divided q24h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Ledipasvir/sofosbuvir (Harvoni): ≥12 yrs or ≥35 kg </td>
      
         <td class="ped-col-2">1 tab q24h. Geno 1: tx-naive, no cirr or comp=12 wks; tx-exp, no cirr=12 wks; tx-exp with comp=24 wks. Geno 4,5,6: tx-naive/exp, no cirr or comp=12 wks
 </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/oseltamivir"> Oseltamivir &lt;1 year old </a></td>
      
         <td class="ped-col-2">6 mg/kg/day (divided q12h) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/oseltamivir"> Oseltamivir ≥ 1 year old </a></td>
      
         <td class="ped-col-2">&lt;15 kg 30 mg bid;
&gt;15 to 23 kg 45 mg bid;
&gt;23 to 40 kg 60 mg bid;
&gt;40 kg 75 mg bid (adult dose) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/peramivir"> Peramivir </a></td>
      
         <td class="ped-col-2">Not studied </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"> Ribavirin (with sofosbuvir) </td>
      
         <td class="ped-col-2">wt &lt;47 kg: 15 mg/kg/day; 47-49 kg, 600 mg/day; 50-65 kg, 800 mg/day; 66-80 kg, 1000 mg/day; &gt;80 kg, 1200 mg/day (all doses divided bid) </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"> Sofosbuvir (≥12 yrs or ≥35 kg) </td>
      
         <td class="ped-col-2">400 mg q24h. Geno 2: tx-naive/exp, no cirr or comp=12 wks (with ribavirin). Geno 3: tx-naive/exp, no cirr or comp=24 wks (with ribavirin). </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/valacyclovir"> Valacyclovir (Varicella or Herpes Zoster) </a></td>
      
         <td class="ped-col-2">60 mg/kg/day (divided q8h) </td>
         <td class="ped-col-3">3 gm  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/valganciclovir"> Valganciclovir </a></td>
      
         <td class="ped-col-2">Symptomatic congenital CMV 32 mg/kg/day (divided q12h);
Prevention of CMV after SOT: 7 mg x BSA x CrCl (once daily; use Schwartz formula for CrCl). </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trEven drugRow">
         <td class="ped-col-1"><a class="tableLink" href="/sanford-guide-online/drug-information/antiviral-agents/zanamavir"> Zanamivir (age &gt;7 years) </a></td>
      
         <td class="ped-col-2">10 mg (two 5-mg inhalations) twice daily </td>
         <td class="ped-col-3">  </td>
       </tr>
       <tr class="tblCell trOdd drugRow">
         <td class="ped-col-1">  </td>
      
         <td class="ped-col-2"> </td>
         <td class="ped-col-3">  </td>
       </tr>
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